منابع مشابه
Leukotrienes and kidney diseases
PURPOSE OF REVIEW This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS Since last reviewed in 1994, leukotrienes were shown to mediate drug-associated...
متن کاملLeukotrienes and leukotriene modifiers in pediatric allergic diseases
Leukotrienes are potent pro-inflammatory lipid mediators derived from arachidonic acid through several enzymatic pathways. They have an essential role in allergic inflammation, where they induce bronchoconstriction, airway edema, and chemotaxis of the inflammatory cells in the airways, nasal and conjunctival tissues. Leukotriene modifiers include leukotriene receptor antagonists (montelukast, z...
متن کاملNeurologic manifestations in children and adolescents with chronic kidney diseases
Background and Objective: Chronic renal failure (CRF) may have many effects on nervous system and manifest as headache, seizure, dialysis disequilibrium syndrome, cerebral hemorrhage, hypertensive encephalopathy, uremic neuropathy, and some neurologic complications of transplantation. In this present study we investigate neurologic disorders in children with CRF. Methods: In this descriptive...
متن کاملCysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases
Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader range of inflammation-associated diseases such as cancer, atopic dermatitis, rheumatoid arthritis, and cardiovascular diseases. The reported elevated levels of CysLTs in acute and chronic brain lesions, the asso...
متن کاملkiDney Diseases
Introduction. Recent studies have suggested theophylline for prevention of kidney dysfunction in asphyxia. This study was designed to determine whether theophylline could prevent or ameliorate kidney dysfunction in term neonates with perinatal asphyxia. Materials and Methods. We assigned 36 severely asphyxiated term infants (Apgar score ≤ 5) into 2 groups to receive intravenously a single dose ...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2018
ISSN: 1062-4821
DOI: 10.1097/mnh.0000000000000381